3 July 2020
Huanhuan Jiang, C. M. Sabbir Ahmed, Thomas J. Martin, Alexa Canchola, Iain W. H. Oswald,Jose Andres Garcia, Jin Y. Chen, Kevin A. Koby, Anthony J. Buchanan, Zixu Zhao, Haofei Zhang, Kunpeng Chen, and Ying-Hsuan Lin*, ACS Publications:
Recent reports have linked severe lung injuries and deaths to the use of e-cigarettes and vaping products. Nevertheless, the causal relationship between exposure to vaping emissions and the observed health outcomes remains to be elucidated. Through chemical and toxicological characterization of vaping emission products, this study demonstrates that during vaping processes, changes in chemical composition of several commonly used vape juice diluents (also known as cutting agents) lead to the formation of toxic byproducts, including quinones, carbonyls, esters, and alkyl alcohols. The resulting vaping emission condensates cause inhibited cell proliferation and enhanced cytotoxicity in human airway epithelial cells. Notably, substantial formation of the duroquinone and durohydroquinone redox couple was observed in the vaping emissions from vitamin E acetate, which may be linked to acute oxidative stress and lung injuries reported by previous studies. These findings provide an improved molecular understanding and highlight the significant role of toxic byproducts in vaping-associated health effects.