This toolkit presents a range of issues, policy options, and considerations that each country needs to take into account for purposes of developing country efforts for the implementation of Article 5.3 related to protection of tobacco control measures from interference by the tobacco industry of the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC). It describes guiding principles, steps for effective Article 5.3 implementation; common practices and motives used by tobacco industry in interference as well as illustrates the toolkit implementation guides including strategic planning, checklist for developing a strategy and for Article 5.3 focal teams. Case study of Philippines is included. The toolkit also provides some policy templates that can assist in the implementation of Article 5.3 and its expected output and impact on policies.