The views expressed in this manuscript are those of the authors and therefore do not necessarily reflect the respective policies of the American Heart Association, Inc., the World Heart Federation, the American College of Cardiology, or the European Society of Cardiology.

The article has been copublished with permission in the European Heart Journal, the Journal of the American College of Cardiology, Circulation, and Global Heart. © The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The articles are identical except for minor stylistic and spelling differences in keeping with each journal’s style. When citing this article, a citation from any of the journals listed is appropriate.

How to cite this article: Willett J, Achenbach S, Pinto FJ, Poppas A, Elkind MSV. The tobacco endgame—eradicating a worsening epidemic: a joint opinion from the American Heart Association, World Heart Federation, American College of Cardiology, and the European Society of Cardiology. J Am Coll Cardiol. 2021 May 26 [E-pub ahead of print].

Disclosures Dr Elkind serves as an unpaid Officer of the American Heart Association. Dr Poppas reports financial interest in GE. The other authors report no conflicts of interest.